Pii: S0304-3940(99)00426-7
نویسندگان
چکیده
Butyrylcholinesterase (BCHE) is an enzyme expressed in most human tissues. Recently, an increased odds of carrying the K variant of BCHE (BCHE-K) was reported among Alzheimer disease (AD) cases as compared with controls. We tested our data set of 245 sporadic AD cases and 241 controls for an association between BCHE-K, APOE4, and AD using logistic regression and chi-square analyses. The sib transmission disequilibrium test (S-TDT) was also used to test for differences in BCHE-K allele frequencies between 163 discordant sib-pairs selected from multiplex AD families. No statistically signi®cant differences were noted between BCHE-K case and control allele frequencies even after stratifying by APOE4 status. S-TDT analysis between the BCHE-K variant and AD was also not signi®cant (P 0:52). We conclude that BCHE-K is not a major genetic risk factor for AD in our study population. q 1999 Elsevier Science Ireland Ltd. All rights reserved.
منابع مشابه
Pii: S0304-3940(99)00302-x
This study sought to analyze the postural responses induced by separately or simultaneously vibrating with different frequencies the forefoot and rear foot zones of both soles in standing subjects. Stimulating each zone separately resulted in spatially oriented body tilts; their amplitude and velocity varied linearly according to the frequency, and their direction was always opposite to the pla...
متن کاملPii: S0304-3940(99)00913-1
To determine the role of cytokines in the nervous system, we examined the effect of interleukin-12(IL-12) on the nerve regeneration of mouse superior cervical ganglion cells (SCG). IL-12 enhanced the neurite outgrowth in a concentrationdependent manner. Immunocytochemical studies demonstrated the expression of IL-12 receptors in neuronal bodies and neurites. The mRNA expression of IL-12 recepto...
متن کاملPii: S0304-3940(99)00152-4
Event-related potentials (ERPs) were recorded while subjects monitored a visually presented sequence of stimuli that provided information about both a temporal pattern (rhythm) and a spatial pattern, and responded to rhythmical or spatial deviants. A third task, which required the monitoring of the same sequence for screen flickers served as a perceptual baseline condition and controlled for re...
متن کاملPii: S0304-3940(99)00390-0
In the ̄occulus of pigeons, as in other species, there are two major types of Purkinje cell responses to rotational optokinetic stimuli. One type prefers rotation about the vertical axis (VA neurons) whereas the other prefers rotation about an horizontal axis oriented at 1358 ipsilateral azimuth (H-135 neurons). In this study, we injected the retrograde tracer cholera toxin subunit B into the V...
متن کاملPii: S0304-3940(99)00386-9
We examined the change of corticostriatal glutamatergic neuronal transmission in striatal slices of methamphetamine (MAP)-sensitized rats in vitro. Tetanic stimulation induced long-term depression (LTD) of the ®eld potential in the striatum of saline-treated rats. However, it induced long-term potentiation (LTP) in the striatum of MAP-sensitized rats. This LTP was signi®cantly suppressed by a N...
متن کامل